BDBM50207145 CHEMBL3946995::US9550741, I-1

SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1ccco1

InChI Key InChIKey=AAELEHAFAYIZRH-WGSAOQKQSA-N

Data  12 KI  5 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50207145   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM50207145(CHEMBL3946995 | US9550741, I-1)
Affinity DataKi:  1.30nMpH: 7.4Assay Description:1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM50207145(CHEMBL3946995 | US9550741, I-1)
Affinity DataKi:  1.30nMpH: 7.4Assay Description:1. Experimental Materials:The isotopic ligand of 5-H1A receptor [3H]0.8-OH-DPAT (purchased from PE Corporation), (+)5-hydroxytryptamine (purchased fr...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM50207145(CHEMBL3946995 | US9550741, I-1)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM50207145(CHEMBL3946995 | US9550741, I-1)
Affinity DataIC50:  46nMAssay Description:Antagonistic activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM50207145(CHEMBL3946995 | US9550741, I-1)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at 5-HT1A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 by Fluo-4 dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed